Dr. Otto Octavius, genius scientist and inventor, creates a tool allowing him to work with radioactive materials with relative safety and ease.

But even the incredible artificial arms cannot protect the scientist from human error. An explosion tears through his lab. Octavius survives, but there are complications ....

The deranged doctor discovers that he has mental control over his mechanical arms. He takes on the identity of Doctor Octopus and begins his quest to conquer the world. Only Spiderman stands in his way ....

Spiderman manages to defeat the insane criminal. But Doctor Octopus returns again and again seeking ultimate power. Doctor Octopus even forms the Sinister Six, recruiting various enemies of Spiderman to battle his wall-crawling nemesis.

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