An inventor with a genius level intellect, Bentley Wittman, calling himself the Wizard, uses anti-gravity disks and power gloves among other inventions against the Fantastic Four. As the leader of the Frightful Four, he rebuilds the team each time they are defeated.
Medusa, one of the royal family of Inhumans, loses her memory when she is separated from her kind. The Wizard finds her and takes her in. Endowed with hair that she can animate like added appendages, she joins the Frightful Four, escaping when the others are captured. Later, she regains her memory and returns to the Inhumans.

William Baker, aka Flint Marko, escapes from a federal penitentiary and hides at a nuclear test site. While lying on a nearby beach, he is accidently bombarded with a massive dose of radiation. Marko awakes to find that he can transform his body into an animated, sand-like substance. As the Sandman, he battles Spiderman, the Fantastic Four and the Hulk, both on his own and as part of the Frightful Four.
Originally a brilliant research chemist, Peter Petruski invents a super-adhesive and turns to crime as "Paste Pot Pete". Learning he has a knack for setting traps, he becomes the Trapster and ensnares various victims and superheroes alike.
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